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1

Development of selective agonists and antagonists of P2Y receptors

Kenneth A. Jacobson, Andrei A. Ivanov, Sonia de Castro, T. Kendall Harden, Hyojin Ko

Journal:

Purinergic Signalling

Year:

2009

Language:

english

File:

PDF, 498 KB

english, 2009

2

REGULATION OF PHOSPHOLIPASE C ISOZYMES BY RAS SUPERFAMILY GTPASES

Harden, T. Kendall, Sondek, John

Journal:

Annual Review of Pharmacology

Year:

2006

Language:

english

File:

PDF, 644 KB

english, 2006

3

4-Alkyloxyimino Derivatives of Uridine-5′-triphosphate: Distal Modification of Potent Agonists as a Strategy for Molecular Probes of P2Y 2 , P2Y 4 , and P2Y 6 Receptors

Jayasekara, P. Suresh, Barrett, Matthew O., Ball, Christopher B., Brown, Kyle A., Hammes, Eva, Balasubramanian, Ramachandran, Harden, T. Kendall, Jacobson, Kenneth A.

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.47 MB

english, 2014

4

Potent and Selective Peptide-based Inhibition of the G protein Gαq

Charpentier, Thomas H, Waldo, Gary L, Lowery-Gionta, Emily G, Krajewski, Krzysztof, Strahl, Brian D, Kash, Thomas L, Harden, T. Kendall, Sondek, John

Journal:

Journal of Biological Chemistry

Year:

2016

Language:

english

File:

PDF, 1.28 MB

english, 2016

5

Avian and human homologues of the P2Y1 receptor: Pharmacological, signaling, and molecular properties

Jose L. Boyer, Joel B. Schachter, Susan M. Sromek, R. Kyle Palmer, Kenneth A. Jacobson, Robert A. Nicholas, T. Kendall Harden

Journal:

Drug Development Research

Year:

1996

Language:

english

File:

PDF, 835 KB

english, 1996

6

Receptor nomenclature

Bertil B. Fredholm, Geoffrey Burnstock, T. Kendall Harden, Michael Spedding

Journal:

Drug Development Research

Year:

1996

Language:

english

File:

PDF, 533 KB

english, 1996

7

Synthesis and structure-activity relationships of pyridoxal-6-arylazo-5′-phosphate and phosphonate derivatives as P2 receptor antagonists

Yong-Chul Kim, Emidio Camaioni, Airat U. Ziganshin, Xiao-duo Ji, Brian F. King, Scott S. Wildman, Alexei Rychkov, Joshua Yoburn, Heaok Kim, Arvind Mohanram, T. Kendall Harden, José L. Boyer, Geoffrey

Journal:

Drug Development Research

Year:

1998

Language:

english

File:

PDF, 291 KB

english, 1998

8

ChemInform Abstract: Acyclic Analogues of Deoxyadenosine 3′,5′-Bisphosphates as P2Y1 Receptor Antagonists.

Yong-Chul Kim, Carola Gallo-Rodriguez, Soo-Yeon Jang, Erathodiyil Nandanan, Mary Adams, T. Kendall Harden, Jose L. Boyer, Kenneth A. Jacobson

Journal:

Year:

2000

File:

PDF, 32 KB

2000

9

ChemInform Abstract: Structurally Related Nucleotides as Selective Agonists and Antagonists at P2Y1 Receptors

Kenneth A. Jacobsen, Stefano Moro, Carsten Hoffmann, Yong-Chul Kim, Hak Sung Kim, R. Gnana Ravi, T. Kendall Harden, Jose L. Boyer

Journal:

Year:

2001

File:

PDF, 27 KB

2001

10

Interplay of constitutively released nucleotides, nucleotide metabolism, and activity of P2Y receptors

Eduardo R. Lazarowski, Richard C. Boucher, T. Kendall Harden

Journal:

Drug Development Research

Year:

2001

Language:

english

File:

PDF, 143 KB

english, 2001

11

Structure activity relationships for derivatives of adenosine-5′-triphosphate as agonists at P2 purinoceptors: Heterogeneity within P2x and P2y subtypes

Geoffrey Burnstock, Bilha Fischer, Charles H. V. Hoyle, Michel Maillard, Airat U. Ziganshin, Antonia L. Brizzolara, Amy von Isakovics, José L. Boyer, T. Kendall Harden, Dr. Kenneth A. Jacobson

Journal:

Drug Development Research

Year:

1994

Language:

english

File:

PDF, 1.26 MB

english, 1994

12

Studies of cAMP metabolism in cultured hepatoma cells: Presence of functional adenylate cyclase despite low camp content and lack of hormonal responsiveness

Ben H. Leichtling, Y.-F. Su, Jayantha Wimalasena, T. Kendall Harden, Barry B. Wolfe, Wesley D. Wicks

Journal:

Journal of Cellular Physiology

Year:

1978

Language:

english

File:

PDF, 743 KB

english, 1978

13

Platelet-derived growth factor and angiotensin II cause increases in cytosolic free calcium by different mechanisms in vascular smooth muscle cells

Dr. Michael W. Roe, John R. Hepler, T. Kendall Harden, Brian Herman

Journal:

Journal of Cellular Physiology

Year:

1989

Language:

english

File:

PDF, 1004 KB

english, 1989

14

DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms

Kevin D. Healy, Louis Hodgson, Tai-Young Kim, Adam Shutes, Savitri Maddileti, Rudolph L. Juliano, Klaus M. Hahn, T. Kendall Harden, Yung-Jue Bang, Channing J. Der

Journal:

Molecular Carcinogenesis

Year:

2008

Language:

english

File:

PDF, 392 KB

english, 2008

15

Development of an Assay for Phospholipase C Using Column-Reconstituted, Extruded Phospholipid Vesicles

Chang-Seon Myung, Andrew Paterson, T.Kendall Harden, James C. Garrison

Journal:

Analytical Biochemistry

Year:

1999

Language:

english

File:

PDF, 247 KB

english, 1999

16

C(8)-Substituted 1-azabicyclo[3.3.1]non-3-enes: a novel scaffold for muscarinic receptor ligands

Myoung Goo Kim, Erik T Bodor, T Kendall Harden, Harold Kohn

Journal:

Bioorganic & Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 394 KB

english, 2004

17

Nucleotide analogues containing 2-oxa-bicyclo[2.2.1]heptane and l-α-threofuranosyl ring systems: interactions with P2Y receptors

Michihiro Ohno, Stefano Costanzi, Hak Sung Kim, Veerle Kempeneers, Karen Vastmans, Piet Herdewijn, Savitri Maddileti, Zhan-Guo Gao, T. Kendall Harden, Kenneth A. Jacobson

Journal:

Bioorganic & Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 554 KB

english, 2004

18

Synthesis and P2Y receptor activity of nucleoside 5′-phosphonate derivatives

Liesbet Cosyn, Serge Van Calenbergh, Bhalchandra V. Joshi, Hyojin Ko, Rhonda L. Carter, T. Kendall Harden, Kenneth A. Jacobson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 398 KB

english, 2009

19

Molecular recognition in the P2Y14 receptor: Probing the structurally permissive terminal sugar moiety of uridine-5′-diphosphoglucose

Hyojin Ko, Arijit Das, Rhonda L. Carter, Ingrid P. Fricks, Yixing Zhou, Andrei A. Ivanov, Artem Melman, Bhalchandra V. Joshi, Pavol Kováč, Jan Hajduch, Kenneth L. Kirk, T. Kendall Harden, Kenneth A. J

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 2.53 MB

english, 2009

20

Molecular dynamics simulation of the P2Y14 receptor. Ligand docking and identification of a putative binding site of the distal hexose moiety

Andrei A. Ivanov, Ingrid Fricks, T. Kendall Harden, Kenneth A. Jacobson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 449 KB

english, 2007

21

Ligand and structure-based methodologies for the prediction of the activity of G protein-coupled receptor ligands

Stefano Costanzi, Irina G. Tikhonova, T. Kendall Harden, Kenneth A. Jacobson

Journal:

Journal of Computer-Aided Molecular Design

Year:

2009

Language:

english

File:

PDF, 214 KB

english, 2009

22

GPR80/99, proposed to be the P2Y15receptor activated by adenosine and AMP, is not a P2Y receptor

Ai-Dong Qi, T. Kendall Harden, Robert A. Nicholas

Journal:

Purinergic Signalling

Year:

2004

Language:

english

File:

PDF, 357 KB

english, 2004

23

Delineation of ligand binding and receptor signaling activities of purified P2Y receptors reconstituted with heterotrimeric G proteins

Erik T. Bodor, Gary L. Waldo, Rainer Blaesius, T. Kendall Harden

Journal:

Purinergic Signalling

Year:

2004

Language:

english

File:

PDF, 302 KB

english, 2004

24

Regulation of Cyclic AMP Accumulation by Peptide Hormone Receptors in Immunocytochemically: Defined Astroglial Cells

Tony Evans, Ken D. McCarthy, T. Kendall Harden

Journal:

Journal of Neurochemistry

Year:

1984

Language:

english

File:

PDF, 898 KB

english, 1984

25

Ser352 and Ser354 in the carboxyl terminus of the human P2Y1 receptor are required for agonist-promoted phosphorylation and internalization in MDCK cells

Ai-Dong Qi, Dayle Houston-Cohen, Isabella Naruszewicz, T Kendall Harden, Robert A Nicholas

Journal:

British Journal of Pharmacology

Year:

2011

Language:

english

File:

PDF, 1.31 MB

english, 2011

26

Bupropion does not antagonize cardiovascular actions of clonidine in normal subjects and spontaneously hypertensive rats

Cubeddu, Luigi X, Cloutier, Gilles, Gross, Kirsten, Grippo, Richard, Tanner, Laura, Lerea, Leslie, Shakarjian, Michael, Knowlton, Gail, Harden, T Kendall, Arendshorst, William

Journal:

Clinical Pharmacology & Therapeutics

Year:

1984

Language:

english

File:

PDF, 627 KB

english, 1984

27

A unique fold of phospholipase C-β mediates dimerization and interaction with Gαq

Singer, Alex U., Waldo, Gary L., Harden, T. Kendall, Sondek, John

Journal:

Natural Structural Biology

Year:

2001

Language:

english

File:

PDF, 2.90 MB

english, 2001

28

Crystal structure of the multifunctional Gβ5–RGS9 complex

Cheever, Matthew L, Snyder, Jason T, Gershburg, Svetlana, Siderovski, David P, Harden, T Kendall, Sondek, John

Journal:

Nature Structural and Molecular Biology

Year:

2008

Language:

english

File:

PDF, 1.26 MB

english, 2008

29

Crystal structure of Rac1 bound to its effector phospholipase C-β2

Jezyk, Mark R, Snyder, Jason T, Gershberg, Svetlana, Worthylake, David K, Harden, T Kendall, Sondek, John

Journal:

Nature Structural and Molecular Biology

Year:

2006

Language:

english

File:

PDF, 410 KB

english, 2006

30

An examination of deoxyadenosine 5′(α-thio)triphosphate as a ligand to define P2Y receptors and its selectivity as a low potency partial agonist of the P2Y1 receptor

Joel B Schachter, T Kendall Harden

Journal:

British Journal of Pharmacology

Year:

1997

Language:

english

File:

PDF, 377 KB

english, 1997

31

Fidelity in functional coupling of the rat P2Y1 receptor to phospholipase C

Joel B. Schachter, José L. Boyer, Qing Li, Robert A. Nicholas, T. Kendall Harden

Journal:

British Journal of Pharmacology

Year:

1997

Language:

english

File:

PDF, 292 KB

english, 1997

32

Competitive and selective antagonism of P2Y1 receptors by N6-methyl 2′-deoxyadenosine 3′,5′-bisphosphate

José L Boyer, Arvind Mohanram, Emidio Camaioni, Kenneth A Jacobson, T Kendall Harden

Journal:

British Journal of Pharmacology

Year:

1998

Language:

english

File:

PDF, 280 KB

english, 1998

33

Quantitation of extracellular UTP using a sensitive enzymatic assay

Eduardo R Lazarowski, T Kendall Harden

Journal:

British Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 182 KB

english, 1999

34

Functional expression of a cDNA encoding a human ecto-ATPase

Jesús Mateo, T Kendall Harden, José L Boyer

Journal:

British Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 645 KB

english, 1999

35

The stable pyrimidines UDPβS and UTPγS discriminate between the P2 receptors that mediate vascular contraction and relaxation of the rat mesenteric artery

Malin Malmsjö, Mikael Adner, T Kendall Harden, William Pendergast, Lars Edvinsson, David Erlinge

Journal:

British Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 148 KB

english, 2000

36

Differential coupling of the human P2Y11 receptor to phospholipase C and adenylyl cyclase

Ai-Dong Qi, Charles Kennedy, T Kendall Harden, Robert A Nicholas

Journal:

British Journal of Pharmacology

Year:

2001

Language:

english

File:

PDF, 185 KB

english, 2001

37

2-Chloro N6-methyl-(N)-methanocarba-2′-deoxyadenosine-3′,5′-bisphosphate is a selective high affinity P2Y1 receptor antagonist

José L Boyer, Mary Adams, R Gnana Ravi, Kenneth A Jacobson, T Kendall Harden

Journal:

British Journal of Pharmacology

Year:

2002

Language:

english

File:

PDF, 181 KB

english, 2002

38

[32P]2-iodo-N6-methyl-(N)-methanocarba-2′-deoxyadenosine-3′,5′-bisphosphate ([32P]MRS2500), a novel radioligand for quantification of native P2Y1 receptors

Dayle Houston, Michihiro Ohno, Robert A Nicholas, Kenneth A Jacobson, T Kendall Harden

Journal:

British Journal of Pharmacology

Year:

2006

Language:

english

File:

PDF, 211 KB

english, 2006

39

A PLCβ/PI3Kγ-GSK3 Signaling Pathway Regulates Cofilin Phosphatase Slingshot2 and Neutrophil Polarization and Chemotaxis

Wenwen Tang, Yong Zhang, Wenwen Xu, T. Kendall Harden, John Sondek, Le Sun, Lin Li, Dianqing Wu

Journal:

Developmental Cell

Year:

2011

Language:

english

File:

PDF, 1.19 MB

english, 2011

40

Synthesis, Biological Activity, and Molecular Modeling of Ribose-Modified Deoxyadenosine Bisphosphate Analogues as P2Y1 Receptor Ligands

Nandanan, Erathodiyil, Jang, Soo-Yeon, Moro, Stefano, Kim, Hea Ok, Siddiqui, Maqbool A., Russ, Pamela, Marquez, Victor E., Busson, Roger, Herdewijn, Piet, Harden, T. Kendall

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 335 KB

english, 2000

41

Concentration of enzyme-dependent activation of PLC-β1 and PLC-β2 by Gα11 and βγ-subunits

Andrew Paterson, JoséLuis Boyer, Val J. Watts, Andrew J. Morris, Elmer M. Price, T.Kendall Harden

Journal:

Cellular Signalling

Year:

1995

Language:

english

File:

PDF, 880 KB

english, 1995

42

Receptor-induced heterologous desensitization of receptor-regulated phospholipase C

Marie-Christine Galas, T.Kendall Harden

Journal:

European Journal of Pharmacology: Molecular Pharmacology

Year:

1995

Language:

english

File:

PDF, 740 KB

english, 1995

43

G-protein-mediated regulation of phospholipase C: Involvement of βγ subunits

JoséL. Boyer, Andrew Paterson, T.Kendal Harden

Journal:

Trends in Cardiovascular Medicine

Year:

1994

Language:

english

File:

PDF, 1006 KB

english, 1994

44

Antiaggregatory activity in human platelets of potent antagonists of the P2Y1 receptor

Marco Cattaneo, Anna Lecchi, Michihiro Ohno, Bhalchandra V. Joshi, Pedro Besada, Susanna Tchilibon, Rossana Lombardi, Norbert Bischofberger, T. Kendall Harden, Kenneth A. Jacobson

Journal:

Biochemical Pharmacology

Year:

2004

Language:

english

File:

PDF, 237 KB

english, 2004

45

Structure activity and molecular modeling analyses of ribose- and base-modified uridine 5′-triphosphate analogues at the human P2Y2 and P2Y4 receptors

Kenneth A. Jacobson, Stefano Costanzi, Andrei A. Ivanov, Susanna Tchilibon, Pedro Besada, Zhan-Guo Gao, Savitri Maddileti, T. Kendall Harden

Journal:

Biochemical Pharmacology

Year:

2006

Language:

english

File:

PDF, 354 KB

english, 2006

46

Synthesis and P2Y2 receptor agonist activities of uridine 5′-phosphonate analogues

Sara Van Poecke, Matthew O. Barrett, T. Santhosh Kumar, Davy Sinnaeve, José C. Martins, Kenneth A. Jacobson, T. Kendall Harden, Serge Van Calenbergh

Journal:

Bioorganic & Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1008 KB

english, 2012

47

Structure of Gαi1 Bound to a GDP-Selective Peptide Provides Insight into Guanine Nucleotide Exchange

Christopher A. Johnston, Francis S. Willard, Mark R. Jezyk, Zoey Fredericks, Erik T. Bodor, Miller B. Jones, Rainer Blaesius, Val J. Watts, T. Kendall Harden, John Sondek, J. Kevin Ramer, David P. Sid

Journal:

Year:

2005

Language:

english

File:

PDF, 868 KB

english, 2005

48

Structurally related nucleotides as selective agonists and antagonists at P2Y1 receptors

Kenneth A. Jacobson, Stefano Moro, Carsten Hoffmann, Yong-Chul Kim, Hak Sung Kim, R.Gnana Ravi, T.Kendall Harden, José L. Boyer

Journal:

Year:

2001

Language:

english

File:

PDF, 160 KB

english, 2001

49

Multiple P2Y receptors mediate contraction in guinea pig mesenteric vein

Violeta N Mutafova-Yambolieva, Bernadette M Carolan, T.Kendall Harden, Kathleen D Keef

Journal:

General Pharmacology: The Vascular System

Year:

2000

Language:

english

File:

PDF, 239 KB

english, 2000

50

Pharmacological selectivity of the cloned human P2U-purinoceptor: potent activation by diadenosine tetraphosphate

Eduardo R. Lazarowski, William C. Watt, M. Jackson Stutts, Richard C. Boucher, T. Kendall Harden

Journal:

British Journal of Pharmacology

Year:

1995

Language:

english

File:

PDF, 1.86 MB

english, 1995